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When VAPB or PTPIP51 is overexpressed, the contact surface between mitochondria and the ER increases, leading to mitochondrial calcium overload, MPTP opening, release of cytochrome c and ROS, and induction of cell apoptosis

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Activity of urokinase diluted in 0.9% sodium chloride injection or 5% dextrose injection and stored in glass or plastic syringes