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A report from the Framingham Offspring Study of 2,999 adults found the following average daily B12 intakes, including fortified foods and supplements (Tucker, 2000): Age 26-49: 8.9 µg Age 50-64: 8.7 µg Age 65-83: 8.5 µg A 2015-2016 National Health and Nutrition Examination Survey of over 4,500 adults 60 years and older found the following average daily B12 intakes (USDA NHANES, 2019): Male non-supplement users (68% of men): 4.5 µg Male supplement users: 5.3 µg from food plus 326 µg from supplements Female non-supplement users (63% of women): 3.6 µg Female supplement users: 3.8 µg from food plus 520 µg from supplements European Food Safety Authority’s Recommendations In 2015, the EFSA released recommendations for B12 intake across Europe

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Researchers frequently utilise AOD-9604 in controlled experimental models designed to explore receptor interactions, intracellular communication mechanisms and peptide signalling dynamics