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The three key active components in its Brightening Renewal Cream are: Probiotics: Topical probiotics have shown some promise in research as a potential treatment for certain inflammatory skin conditions (like acne, rosacea, and psoriasis), and topicals containing the specific strain used in this product, Bacillus coagulans , may be able to reduce signs of skin aging.51 52 Apple and grape stem cells: Plant stem cells have some evidence suggesting they might help inflammatory hyperpigmentation.53 Apple stem cells, in particular, have shown “significant potential” in reducing wrinkles around the eyes, though the evidence overall is quite weak and not nearly as substantial as other traditional Vitamin A-derived topicals.54 Additionally, grape contains resveratrol, which may reduce the appearance of hyperpigmentation.55 Vitamin C: An ingredient with evidence suggesting positive effects on hyperpigmentation with long-term use.56 Pricing For a one-time purchase direct from Andalou, each 1.7oz jar of Renewal Cream costs $28.99