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Your provider may need to evaluate for underlying conditions such as hypothyroidism, Cushing's syndrome, polycystic ovary syndrome, or other hormonal imbalances that can cause weight gain independent of tirzepatide therapy

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Studies have demonstrated measurable lipolytic activity in adipose tissue while confirming the absence of significant changes in blood glucose, insulin sensitivity, or IGF-1 levels, validating its utility as a targeted research tool for studying fat metabolism pathways independently of growth axis effects