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Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone (SURPASS) studies have shown that tirzepatide reduced HbA1c and fasting glucose levels more than the titrated insulin degludec, insulin glargine or 1 mg once a week semaglutide independently of the baseline levels of HbA1c

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In vitro measures show that extended wakefulness (i.e., sleep deprivation, SD) impairs hippocampal LTP dependent on cAMP/PKA/CREB signaling, but not LTP that requires new translation (Vecsey et al., 2009)