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Remarkably, TZDs performed an ability to suppress ferroptosis though selectively inhibiting ACSL4 and reduce mortality in kidney-specific Gpx4 knockout mice (193, 194)

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In the presence of another molecule of hydrogen peroxide, Compound II is transformed into the inactive intermediate oxyferrous Compound III, [(Fe II -O 2 (porphyrin)], according to the reaction (Glorieux and Calderon 2017