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As examples, one study found that the requirements for glutamine undergo changes upon transition from monolayer culture to anchorage-independent culture [7], and another study found that glutamine catabolism was not required for tumorigenesis in vivo in some mouse models, which led to the conclusion that glutamine metabolism may not have a role in cancer [13]

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Science (New York, N.Y.) 2019, 364, 636–637