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It's far more economical, to say nothing of infinitely more humane, to block pain DURING surgery c 50 mg ketamine (not 0.5 mg/kg) 2-3 minutes pre-incision + regional analgesia, than to have to treat pain AFTER surgery Got opioid free anesthesia (OFA), brain monitoring

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This is because the formation of alkyl mesylates would require a chemical reaction known as nucleophilic substitution, where a mesylate ion acts as a nucleophile (electron donor) and displaces a hydroxide ion from an alcohol to form the alkyl mesylate