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Disruption of this balance can trigger ferroptosis and other forms of regulated cell death, positioning redox adaptation as a critical vulnerability in cancer

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Important chemical contaminants reported to cause neurotoxic effects in humans at environmentally relevant levels of exposure include polychlorinated biphenyls (Schantz et al., 2003), arsenic (Wasserman et al., 2004), lead (Lanphear et al., 2005), manganese (Takser et al., 2003), pesticides (Rauh et al., 2006), polycyclic aromatic hydrocarbons (Perera et al., 2006) and mercury compounds (Grandjean et al., 1997