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Topical side effects: Mild irritation or redness Temporary dryness in sensitive skin Injectable side effects: Injection site irritation or swelling Mild fatigue (rare) Headache in some users Compared to many therapies, ghk-cu peptide has a relatively low side effect profile, especially when dosed correctly

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The surfactants used and also the prepared niosomes are biodegradable, biocompatible and non-immunogenic (Sankhyan and Pawar, 2012)