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This is manifested in prolonged t max (time to reach maximum observed plasma concentration, C max ) of MMF by approximately 1.5 h compared to the reference DMF (4.03 h and 2.5 h, respectively), and by approximately 1 h compared to diroximel fumarate (4.0 h and 3.0 h, respectively), after oral administration of Bafiertam™, Tecfidera ® and Vumerity ® to healthy volunteers [48,58]

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Patting motion is the way to go to prevent further friction during application