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In the limiting case where the ionization is completely suppressed by pH (for bases, for example, at high pH) a distribution coefficient (D) can be defined mathematically (for bases): Here B is the uncharged and BH + the charged species, subscript o refers to the organic and subscript w, the water phase

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The conjugation of ACPs to polymers such as polyethylene glycol has also been found to improve dynamics/pharmacokinetics by boosting penetration into desired cancer cells and allowing for additional circulation time (174)