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In human populations, selenium deficiency, due to lack of selenium in the soil, has been found to cause Keshan disease (6, 138, 216, 305), a cardiomyopathy, and Kashin-Beck disease (287, 393), an osteoarthropathy, in part, due to reductions in GPx-1 expression

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Calcific tendonitis: Inflammation over a long period can sometimes result in a build-up of calcium deposits within the rotator cuff tendons