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Through NF-κB, SIRT1 also regulates the expression of genes such as inhibitor of apoptosis protein (IAP) and B-cell lymphoma-2 (Bcl-2) and tumor necrosis factor receptor (TNFR) ( SIRT1 protects against oxidative stress via regulation of FOXO protein acetylation, which is involved in antioxidant processes, apoptosis, and cell proliferation (Wong and Woodcock, 2009)

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10.1371/journal.pone.0143318 194 TjinG.WhiteE