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145 Among other environmental toxins, benzo[a]pyrene (B[a]P)-loaded polystyrene microplastics (PSMPs) have been shown to induce mouse colonic TJ barrier disruption via oxidative stress-induced notch signaling, 146 while a neonicotinoid insecticide, imidacloprid, increased paracellular permeability in vitro by disrupting the TJs through NF-κB-MLCK activation

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doi: 10.3390/antiox12061141