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Increased methylation at Bdnf I, IV, VI, and IX promoters were found in the hippocampus of prenatally stressed mice at postnatal day (PND) 40 compared to controls, which led to a downregulation of Bdnf gene and protein expression [54]

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In this context, accumulation of 4-HNE in cochlear tissue exposed to ototoxic drugs induced the expression of NRF2, which in turn reduced the formation of 4-HNE via a glutathione detoxification mechanism [33]

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