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Since then, 7,8-DHF has attracted wide attention as a high-affinity TrkB small molecule agonist and has been extensively investigated in diseases related to the BDNF-TrkB signaling pathway, including schizophrenia [20], anxiety disorders [21], gastrointestinal diseases [22], metabolic syndrome [23], cardiovascular diseases [24], Huntington’s disease (HD) [25, 26], and Down syndrome (DS) [27-29] (Fig