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doi: 10.1007/s00125-021-05387-6 147 KostopoulouEKalaitzopoulouEPapadeaPSkipitariMRojas GilAPSpiliotisBEet al

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A2M binds to and inactivates the destructive enzymes that break down cartilage, helping to slow joint degeneration, relieve pain, and protect against further damage from osteoarthritis