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Cytokines do not need to function as circulating endocrine molecules to drive subjective sickness symptoms because they can be detected by the sensitive and highly branched afferent vagus nerve, which communicates their presence to the brain via brainstem and triggers neuroinflammation and sickness responses (15, 105, 106)

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MET amplification in metastatic colorectal cancer: An acquired response to EGFR inhibition, not a de novo phenomenon