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For example, P1 was referred by the rheumatologist and was in an assisted wheelchair since the age of 41 years due to her severe and painful foot deformities, joint dislocations, and fatigue

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In contrast to differentiation, induced pluripotency occurs when a cell is reprogrammed to revert to a pluripotent state and becomes what is called an induced pluripotent stem cell (iPSC) (Takahashi and Yamanaka, 2006)