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Receptor-ligand complexes are reversibly activated with forward rate k fr and reverse-rate k rr to yield active complexes C a

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Reads were trimmed using Trimmomatic (version 0.39) with the following parameters: LEADING:20, TRAILING:20, SLIDINGWINDOW:4:15, and MINLEN:20, based on Illumina adapter sequences (CTGTCTCTTATACACATCT, AGATCGGAAGAGCACACGTCTGAACTCCAGTCA, AGATCGGAAGAGCGTCGTGTAGGGAAAGAGTGT)