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Review of the therapeutic potential of Forsythiae Fructus on the central nervous system: active ingredients and mechanisms of action

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Superimposing other ZF–CRBN structures, such as ZNF692, similarly not found engaged with ALV2 in our assays, also finds the compound blocking ZNF692 aZF1 binding, with leucine (L413) replacing the critical Helios serine (S133) that engages ALV2