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Compromised intestinal epithelial barrier due to intestinal epithelial-specific loss of JAM-A induces adaptive immune compensation that protects from colitis The findings in mice manipulated for MLCK or occludin expression differed from those obtained in mice lacking the JAM-A (encoded by F11r)

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(PubMed) If AOD-9604 re-enters mainstream clinical availability through compliant channels, the most responsible use-case will likely be: carefully selected patients, realistic expectations, body composition focus, and as an adjunct—not a centerpiece