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FOXO4-DRI is a D-retro-inverso peptide built from a FOXO4 fragment that binds p53, joined to a cell-penetrating sequence, with a molecular weight near 4.8 kDa

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In solid-phase peptide synthesis (SPPS), even minor contaminants present in the starting amino acids, such as dipeptides, D-isomers, β-alanine, or structurally altered residues, can become unintentionally integrated into the final peptide product