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Moreover, how such a cellular injury would be recognised by the immune system to trigger an inflammatory response and subsequent fibrosis (perhaps in a vain attempt to repair the damage) remains to be elucidated

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However, treatment with H 2 O 2 stimulates the phosphorylation and consequent activation of phospholipase C-γ, which catalyzes the formation of inositol 3,4,5-trisphosphate (IP 3 ) and formation of diacylglycerol (DAG) (93)

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