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Taking into account that xanthine derivatives are widely used medicaments in treatment of different disease (inflammatory diseases, behavioral, neurodegenerative diseases, renal diseases, respiratory diseases, cancer pain etc, (34) the effect of xanthine or hypoxhantine should be considered in explanations of the mechanisms involved in effects of XOR inhibition (35).It is well known that widely used and examinated xanthine derivative is caffeine

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rosea extract (340 mg standardized to a content of rosavin 3.07%/rhodioloside 1.95%), sertraline (50 mg HCI), or a placebo