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Route of Administration The same peptide can have very different effective half-lives depending on how it's delivered: Intravenous : Fastest onset, shortest duration — the peptide enters circulation immediately and is subject to full first-pass clearance Subcutaneous : Slower absorption from the injection site creates a depot effect, often extending effective duration Intramuscular : Similar to subcutaneous but with slightly different absorption kinetics Intranasal : Rapid absorption, bypasses the blood-brain barrier for some peptides, but bioavailability can be variable Oral : Most peptides are destroyed in the GI tract

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Fragment 176-191 is the native, unmodified sequence of this region – a direct copy of the corresponding section of the 191-amino acid hGH molecule