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One of the numerous effects of cAMP, mediated by cAMP-dependent protein kinase A (PKA), is the phosphorylation of cAMP-responsive element-binding protein (CREB), which stimulates MITF transcription 26

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The status of his liver disease was Child-Pugh class A, Eastern Cooperative Oncology Group (ECOG) performance status 0, BCLC stage B and China liver cancer (CNLC) classification stage IIb without extrahepatic metastasis, portal vein thrombosis, or other comorbidities (Fig