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Following injury, macrophages and other innate immune cells rapidly infiltrate the wound site, secreting pro-inflammatory cytokines such as TNF-α, IL-1β and chemokines that orchestrate early inflammatory responses and influence both pain and healing processes [41,42]
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(650) observed no differences in esophageal and rectal temperatures in individuals with T1DM and age-, sex-, and morphology-matched controls during 60 min of cycling at an intensity eliciting 400 W (∼220 W/m 2 ) of heat production in a 35°C, 20% RH environment
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