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The placement of waters was confined to AMY 1 R:Cagri and CTR:Cagri ( N = 1) within the deep binding pocket in order to avoid over interpretation of the cryo-EM maps

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Suckfuell et al., 2014) and a Phase I trial for systemic treatment of solid tumors(Warso et al., 2013), together showing there is precedence for DRI peptides in clinical therapy