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[6] [3] [10] A mild deficiency may not cause any discernible symptoms, but moderate deficiency can cause various symptoms, such as feeling tired, lightheadedness, cold intolerance, pale skin, sore tongue, upset stomach, loss of appetite, numbness or tingling (pins and needles) of the fingers and toes, and vision, cognitive or psychological problems

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Long-term use of antioxidants may interfere with normal immune surveillance functions, while pro-oxidants may cause unintended damage to healthy tissues