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Although astrocytes are reported to possess high proteolytic capacity, including for mHTT, which may explain why fewer aggregates are observed in astrocytes compared to neurons [303,304] , astrocytic autophagy becomes progressively compromised during disease progression

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Sodium tanshinone IIA inhibits high glucose-induced VSMC proliferation and migration by activating the AMPK pathway and its downstream signaling pathways AMPK/p53/p21 and AMPK/NF-kB [210]