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Isolated from human plasma, then reproduced in the lab · 4 peer-reviewed sources cited on this page In 1973, Loren Pickart and Michael Thaler published a short paper describing a tripeptide they had isolated from human plasma that changed how liver cells behaved in culture: it extended the survival of normal liver cells and pushed neoplastic liver cells toward faster growth (Pickart and Thaler, Nature New Biology, 1973, PMID 4349963)