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Although there is some controversy about the leak pathway, with several studies suggesting that it is a mere consequence of transient injury to the epithelium, its existence is somehow supported by the fact that no cellular death or evident damage has been thus far associated with certainty to the pathway (reviewed in [46])

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1 However, when VEGF signaling is dysregulated, various disorders such as cancer, diabetic retinopathy (DR, diabetes-induced retinal vascular disorder), and age-related macular degeneration (AMD, retinal disease characterized by macular degeneration) develop