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Psychological well-being in patients on ‘adequate’ doses of l-thyroxine: results of a large, controlled community-based questionnaire study

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In a large cohort of healthy women attempting conception ( n = 1209 cycles), higher urinary isoflavones were not associated with meaningful changes in cycle length but were linked to lower odds of menstrual irregularity (OR 0.79, 95% CI 0.64–0.98), whereas higher lignan excretion showed slightly increased irregularity risk (OR 1.32, 95% CI 1.06–1.64) [163]