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Supplementing choline (2.6 g per day as phosphatidylcholine for 2 weeks) [31] or betaine (1.5 g, 3 g and 6 g per day for 6 weeks) [32] caused a dose–response, although moderate, reduction of fasting homocysteine compared to the placebo (−1.3 µmol/L to −2.2 µmol/L or −12% to −20%)