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HUBERMAN: In order to find out the lethal dose of something, as you can imagine, unfortunately, the way these studies are done is they give animals more and more, that is higher and higher doses of a given compound, find out at what point about 50% of the population of those animals starts to die, and then that's the so-called LD50, or at least that's one crude way of describing it

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Safety measures needed while using naproxen A few users have tried using more than one NSAID – say, naproxen and ibuprofen or aspirin and naproxen, etc – to obtain a quicker remedy