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[4] The process according to claim 1 or 2, wherein the enzyme is lipase, esterase or protease having a hydrolytic capacity, which is used directly or is immobilized prior to use

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have demonstrated that liver injury mediated by Kupffer cells can promote the proliferation and carcinogenic transformation of bile duct cells by inducing the generation of ROS and the paracrine effect of TNF, thereby activating the JNK signaling pathway