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Individuals with cardiovascular risk factors such as hypertension, high cholesterol, or history of heart attack or bypass surgery are at increased risk of having an NSAID-related cardiovascular event (Conaghan 2012)

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Because it is a natural, biological extract, it contains a vast array of active neurotrophic factors, including BDNF (Brain-Derived Neurotrophic Factor), NGF, and remarkably high levels of GDNF-promoting elements