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PI3K/AKT/mTOR HCC development requires the signaling cascade of PI3K, Akt, and mTOR

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Sleep Quality Metrics Sleep latency — time to fall asleep (track nightly) Sleep duration and wake episodes — total sleep time and number of awakenings Subjective sleep quality — 1-10 scale, recorded each morning before coffee Wearable data — if available, track deep sleep percentage, HRV during sleep, resting heart rate trends Circadian consistency — whether waking and sleeping times are becoming more consistent Blood and Biomarker Testing Telomere length testing — commercial tests available (e.g., via qPCR or Flow-FISH)