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This more physiologic approach allows the body to: Regulate how much NAD+ is produced based on the patient’s needs Potentially avoid rapid spikes in NAD+ levels that can sometimes occur with direct NAD+ infusions In short, the body stays in control of the process, which many providers consider a meaningful benefit

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"Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice." Biochemical Pharmacology