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Notably, the surfaces of Gram-positive and Gram-negative bacteria are rich in lipopolysaccharides and teichoic acid, which result in a net negative charge generated on the cell membrane surface

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Furthermore, it has been demonstrated that psychostimulants and the alpha2-adrenoreceptor agonist guanfacine can occasionally reduce hyperactivity, impulsivity, and inattention in SHR, which lends some support to the model's predictive validity (Myers et al.,1982, Sagvolden,2006)