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This week in Science Advances it was demonstrated that H

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Dosing typically begins at a lower dose, suggested initiation of 20 units (0.2 mL) weekly for the first 4 weeks, then escalates according to a titration schedule: Weeks 1–4: Inject 20 units (0.2 mL) one time per week Weeks 5–8: Inject 40 units (0.4 mL) one time per week Weeks 9–12: Inject 70 units (0.7 mL) one time per week Weeks 13–16: Inject 90 units (0.9 mL) one time per week Weeks 17–20: Inject 120 units (1.2 mL) one time per week Week 21+: Inject 140 units (1.4 mL) one time per week Dosing is determined by the prescribing provider based on patient-specific factors