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Constitutively active form of GPCR increases the chance of phosphorylation by G protein-coupled receptor kinases (GRKs) or other kinases (cAMP-dependent PKA and lipid signaling-activated PKC), and facilitates the binding of β -arrestin to the phosphorylated receptor, blocking G protein interaction with a receptor [22–24]

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Chromatogram: The visual output of a chromatography procedure, such as HPLC