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In vivo studies demonstrated that kratom alkaloids exert central analgesic, anti-anxiety, anti-drug addiction, and antipsychotic effects primarily through activation of central opioidergic, adrenergic, serotoninergic, and dopaminergic neurotransmission systems (Matsumoto et al., 1997

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Transcriptomics reveal different metabolic strategies for acid resistance and gamma-aminobutyric acid (GABA) production in select Levilactobacillus brevis strains