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Therefore, upon recognition of LPS from gut bacteria by TLR4 on skeletal muscle cells, nuclear factor-kappa B (NF-κB) is activated, leading to the production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) (Haddad et al., 2005), and the TNF-a producted by macrophages induces protein degradation and apoptosis in cells during the initial stages of stress response (Li et al., 2005)