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Preliminary results from a 1-year open-label study of adjunctive esmethadone to treat MDD (NCT04855760, RELIANCE-OLS) were publicized via press release, reporting favorable tolerability, a 77.2% response rate (44/57 patients), and a 54.4% remission rate (31/57 patients) at month 12 in previously untreated participants (Table 1) [111]