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In specific embodiments, the methods and compositions further comprise increasing blood levels of cysteine and glycine ( e.g ., cysteinylglycine) to correct GSH deficiency, elevated oxidative stress, inflammation, immunosuppression, endothelial dysfunction, mitochondrial dysfunction, genomic damage, impaired autophagy, impaired mitophagy, insulin resistance, impaired cognition, functional limitation, or a combination thereof

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