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PLGA is a hydrophobic polymer, which is more suited to encapsulate hydrophobic rather than hydrophilic agents via two general methods 4 : (1) Nanoprecipitation, in which PLGA and agents to be encapsulated are dissolved in a “good solvent” and then co-precipitate into nanoparticles upon addition into a non-solvent for both

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The clinical studies on B12-GLP-1 conjugation used chemically bonded molecular compounds, not simply mixed solutions like those found in compounding pharmacies