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Absorption kinetics are broadly similar across the three permitted sites, though there is some evidence from GLP-1 pharmacokinetic literature that abdominal subcutaneous delivery produces slightly faster peak concentration compared to thigh or arm administration

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References Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic The objective of this study was to evaluate the efficacy, onset of action, duration of action, and side effects of 1% diphenhydramine compared with 1% lidocaine when used as a local anesthetic agent